A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects
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چکیده
منابع مشابه
Congenital scalp defects with distal limb reduction anomalies.
Scalp defects occur as an isolated abnormality or in association with other malformations, and familial cases were first reported by Feud et all in 1945 and Tisserand-Perier2 in 1953. In 1945, Adams and Oliver3 were the first to report the distinct association of scalp defects with distal limb anomalies. Later reports in the mid-1970s by Burton et al4 and Scribanu and Temtamy5 showed that the c...
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We have produced a spectrum of limb defects in developing mouse embryos by exposing the mother to smoke from cigarettes with different nicotine concentrations, ethanol, and a combination of ethanol and cigarette smoke. The critical time of exposure was determined to be during day 10 of gestation (vaginal plug=day 0). This time is prior to the critical events which occur between the apical e...
متن کاملLimb reduction defects text.PDF
Of all congenital anomalies, limb reduction defects maintain a high profile with the public. In the early 1960s, high rates of limb reductions were associated with expectant mothers taking the drug thalidomide. As a result of this, congenital anomaly surveillance systems were established to try and prevent further such episodes. In the late 1980s limb reductions were found to be associated with...
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ژورنال
عنوان ژورنال: Differentiation
سال: 2012
ISSN: 0301-4681
DOI: 10.1016/j.diff.2012.01.001